The ability to completely change the look of your document with a couple of mouse clicks is amazing. The first thing you have to get use to is, this isn't Microsoft Word. You don't have to learn to code LaTeX but if you know it already, you can always embed it to your heart's content. This is hands down the easiest way to make structured documents and have them typset with the uber-capable LaTeX system. I'm just getting up to speed with LyX after turning up my nose at it a few times over a few years. For whoever wants to use latex for publishing (or for collaboration), there is no way to escape learning it in the end and using lyx will simply delay the inevitable. I still recommend it as an educational tool for latex or for the people who are not very demanding with their documents (i.e. And I say this after using lyx for 10 years. It is still perfectly usable of course, but add this all up and a modern latex editor with live preview seems to be more practical these days.
UPDATE LYX UPDATE
For the mac there is also the problem is that it is not retina ready and this does not seem to be a priority for the developers (also understandable since it requires an update of the toolkit and all the bindings and probably that is too complicated). But this is understandable as there can be no perfect GUI. The disadvantages is that not everyone uses it so if you collaborate with anyone who doesn't use it (usually your boss) you have to switch to latex and also sometimes in order to publish you need to make micro-adjustments, which are usually one command in latex but require a lot of drilling in lyx. My main usage case was to typeset notes with lots of math and also prototype journal articles. This is a very nice document preparation tool.
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